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    Found the enzyme, which are "guarded" by fat reserves and does not lose weight

    Those who have ever dieted, you know that at some point, whatever you do people, weight stops at one point and no longer wishes to leave. Why is this happening?

    This is probably a kind of defense mechanism of the body, which thousands of years accustomed to accumulate and not to spend: he suddenly realizes that energy reserves are melting, and seeks to preserve what is left. Approximately the same "law of conservation of energy" works for all fat people: they spend less calories, because the body keeps reserves, which can still come in handy.

    The mechanisms underlying these processes still remain incompletely understood. Scientists could not understand what slows down weight loss. But now a team from the University of California in San Diego seems to have found the answer.

    The authors explain that the accumulation weight (including seasonal) is an ancient evolutionary advantage that helped our ancestors survive.

    In the new work they found that the most important "watchman" energy (and therefore, and fat) inventory is an enzyme called TANK-binding kinase 1 (TBK1) and its corresponding gene.

    Studying metabolism in obesity and starvation, the researchers found two so-called feedback loops, which are responsible for the self-regulation system. It's like a home thermostat that responds to temperature change, amplifying or reducing heating of the room, the authors write.

    In studies on mice, he observed the functioning of this complex mechanism. In obesity the body is under chronic stress, which causes inflammation through the activation of the path of NF-KB. This is a transcription factor that controls genes that determine immune response. Among these genes that includes the gene TBK1.

    When this gene is activated, automatically turns off the enzyme called AMP-activated protein kinase (AMPK) is one of the main regulators of energy expenditure. Thus, the reduced ability of cells to burn fat. In other words, this mechanism contributes to a reduction in energy expenditure in obesity.

    According to researchers, the enzyme AMPK also "feel" changes in the rate of energy expenditure when a person goes on a diet. The lack of calories the body, to the amount of energy remained at the same level, let in the consumption of adipocytes (fat cells). AMP-activated protein kinase notices this and starts the work of another enzyme TBK1. And then everything happens in the same scenario – the fat burning slows down.

    Thus, the feedback loop locks the expenditure of energy through an inflammatory process, the authors explain.

    When they blocked production of the enzyme TBK1 in mice with obesity, the consumption of energy recovered and the rodents began to lose weight. But there was something else: the inflammatory response in the body increased. In contrast, if the activation of this enzyme, the inflammation decreased (although not gone completely).

    Specialists conducted a similar experiment on mice, not obese (but not dieters). In this case, disabling TBK1 did not result in any changes. In other words, the enzyme contributes to the accumulation of fat reserves only in two conditions – obesity (existing) and fasting (regardless of whether the suffering from obesity go on a diet).

    According to scientists, this discovery will help develop new methods to combat obesity. The inhibition (suppression) of the enzyme TBK1 has the potential to restore normal calorie consumption, the authors say. Ahead – the development of drugs with desired functions.

    By the way, one already has in mind: it is anti-inflammatory and antiallergic drug amlexanox, which was developed in 1980-ies in Japan for the treatment of asthma.

    In 2017, the team have already tested the drug on mice, which, in addition to obesity, there was also a diabetes of the second type. Then the scientists announced that amlexanox really helped animals lose weight and increase their insulin sensitivity.

    Researchers believe that this drug has enormous potential, though their data will help to find new ways of solving the problem of obesity. The authors also remind anyone who wants to lose weight, that one only a diet will not help: it is necessary not only to reduce calorie intake and increase energy consumption. That was also proved by the researchers in this case.

    Learn more about this work and its outcome is covered in the article, which was published in Cell.

    By the way, before scientists found in the body of the inner "scales" watching fat deposits. In addition, obesity was "socially contagious".

    Friday 09 February 2018 - 22:16:45email to someone printer friendly create pdf of this news item
    The richest Governor got 13 years of strict regime

    The ex-Governor of Sakhalin region Alexander Khoroshavin sentenced to 13 years in strict regime and a fine of half a billion rubles. Impressive terms have been the mediators through whom he scrolled corruption schemes and collected from the entrepreneurs of the tribute for the right to work in the region.

    When the hall will include the judge and the Secretary will ask everyone to stand up, Alexander Horoshavin will only turn their backs on them. He all the time stood, whispering talking with a lawyer. Former Sakhalin Governor distantly hears the sentence. From the first words of the judges is clear — guilty.

    "Recognize khoroshavina guilty of eight crimes under article 290..."—read the judge's sentence.

    Article 290-I is a bribe. As has established a consequence, Khoroshavin and his entourage were doing it a lot. The former Governor of the organized criminal group, which forced the entrepreneurs of the island to pay them.

    "In one case, the entrepreneur was put in onerous conditions, as it demanded a bribe to obtain legal subsidies," — said Svetlana Petrenko, a spokesman for the Investigative Committee of Russia.

    More than five million dollars Khoroshavin, as already proven in court, received as a bribe at the conclusion of the contract for the construction of the fourth power unit of Yuzhno-Sakhalinskaya CHPP. In just six years, the former head of the region together with businesses more than half a billion rubles.

    "I believe that I have left certain obligations that I must fulfill. Left debt that I have to give," said Khoroshavin.

    He's guilty, of course, denied. Claimed in court that none of the witnesses the prosecution did not know personally. However, for that he had comrades-in-arms adviser Andrey Ikramov, Deputy, Sergei Karakin, Minister of agriculture Nikolai Borisov. They are now beside him in the dock.

    "All entrepreneurs questioned in court, as one said, were forced to pay to the Governor because of their company, employing hundreds of thousands of employees, have coped with the problems," says Denis Shtunder, senior Prosecutor of the Department of public prosecutors of the Prosecutor General of the Russian Federation.

    At the direction of the prizes, the money was transferred to accounts of offshore companies was transferred to Bank cards and exchanged for foreign currency.

    That's where untold riches, which showed in March 2015, the arrested Governor. Four apartments in the capital region is 240 million, six vehicles, including a Mercedes, two Bentley, a pair of "Lexus". The entire fleet will cost $ 40 million. Jewelry. A large amount of cash in rubles and in foreign currency — for the seven hundred million. No wonder in 2009, he was named the richest Governor of Russia.

    While under arrest, he was very upset that the property was confiscated. Although why he is in jail, and now in the colony, such luxury? It is not necessary. The verdict of the court he ten years — nearly three already served, will be in the state-owned grub.

    Friday 09 February 2018 - 22:16:34email to someone printer friendly create pdf of this news item
    The cards are dealt according to a new Putin has warned businesses about the changing landscape of the global economy

    Nothing to do with Ukraine or Crimea economic sanctions against Russia have not. About Vladimir Putin said at the Congress of RSPP. Sanctions are related to competition. In this case, unfair. But the cards are now dealt new, warned the President. The emergence of new markets and new leaders. And the Russian business it is important not to miss the moment. In response, entrepreneurs are asked to trust them.

    The President's speech at the Congress of entrepreneurs has become a tradition. Vladimir Putin began with recent decisions aimed at support and development of Russian business. The head of state reminded that today the state Duma adopted in the third reading a package of laws providing for the extension of the Amnesty until February 28, 2019.

    "I will not hide, many of you know, we consulted on this issue and with international financial organizations. They treat this with understanding and support us in this decision. I hope that this step towards the Russian business will give it additional stability, and will create new opportunities for those who want honest, civilized vbeluyu to work in Russia, to create businesses and new jobs," — said Putin.

    Recently, Putin met with representatives of large French business. The meeting discussed the development of mutual business relations. The Europeans want to work in the Russian market and with Russian business. On common interests is increasingly hampered by the sanctions regime.

    "It's a dead-end path, which leads everyone, including themselves the initiators of such policies to loss of profits and direct losses. I must say that communicating with your colleagues from other countries, I see that they have this view is shared, — continued the President of Russia. — Restriction policy, as you know, it was a very long time, always in fact. The amendment of Jackson-Vanik amendment was abolished, and then, almost in the same day, and, in my opinion, on the same day adopted was the so-called Magnitsky act. Just without any reason. It was still long before any events there in Ukraine, in the Crimea. Just because that's how you want to work with us".

    New technology, reminded the President, seriously change the landscape of the world economy.

    "If so, we can say, today the cards are dealt on the new, will form a fundamentally new markets for goods and services, there will be new leaders, and, of course, that competition now will escalate, warned business Putin. In such a situation with competitors, including in the global business environment, of course, right to say, will not stand on ceremony. In the course can go any form of pressure and any form of competition. It is obvious that the sanctions challenge was not opportunistic in nature and likely will persist for some perspective. But still hope that common sense will prevail, and in the interests of the entire global economy we will move forward together with all our partners in the right direction."

    The leaders of the RSPP has declared readiness of joint implementation by government and business strategies for the coming medium-term period.

    The Congress of the Russian Union of Industrialists and entrepreneurs was held in the framework of Russian business week. In the course of the Congress were discussed the issues of reduction of administrative barriers, optimization of state control and the development of a competitive environment. A lot of the control and Supervisory procedures is one of the most significant problems faced by entrepreneurs.

    "We're not against the surveillance and control because it needs to be protected, public interests, the safety of citizens. But when you have to create a whole division to communicate with the controllers, when not managed to close the door behind one, and should be open to other controllers to work once. And the result — a significant part of the Russian economy is in shadow. We need bring to the light of God," said the President of the Russian Union of Industrialists and entrepreneurs Alexander Shokhin.

    One of the issues discussed at the Congress of the liberalisation of currency regulation.

    "You know, our decision to simplify registration, simplifying foreign exchange legislation, we are going to talk about the cancellation of the implementation of foreign exchange earnings. All of this is designed to help your business back. I believe that the development of business in Russia will be more successful than in the West," — said the Minister of Finance of Russia Anton Siluanov.

    On the sidelines of the Congress talking about what is of concern to Russian business. Oil — on projects in the new world climate: business and the natural.

    "Company "Gazprom Neft" has proved that, in principle, can operate in any climate. And even in the Arctic, as you know, we have successfully completed three projects are very complex, major project. But seriously, I believe that the climate is quite comfortable to work with. And this is confirmed, in particular, and the results of our work", — says the Chairman of the Board, the General Director of "Gazprom Neft" Alexander Dyukov.

    The main owner of Novolipetsk steel Vladimir Lisin decided to draw the President's attention, telling him of the old Soviet joke, making fun of the incompetence of decisions.

    "Farm, is a collection. The Chairman rises and says: "You know, we have a problem. The crop on the nose, and the Smith took to the bottle. Need something to do. Well, any suggestions?"Rises the most advanced and says: "Let's send them for treatment". He says: "What treatment, sowing on the nose, who will repair, a blacksmith, everything was gone, the other not. - Any other suggestions?"Someone says, "Let's take quarterly premium". He says: "Three children, he now simply go to a nearby farm and all, we lost him too. One person, let's take something a little better." Someone says, "Let him face nabem". "What's with you guys? 40 years old man, beat face, he'll turn around and throw all the work, so too it is impossible." Stretches the hand, and said: "And let him iznasiluem". The President throws up his hands: "what are You crazy, what's that?"Stretches the other arm, says: "And let iznasiluem tractor". He says: "Where is the tractor?""And we have two of them". Here are sometimes we therefore make decisions. I'll tell you a concrete example from our practice," — said Putin, the Chairman of the Board of Directors of the Novolipetsk metallurgical combine Vladimir Lisin.

    "Volodya, well I would say about a milkmaid at least! Where you pull, well, where?"asked Lisin Putin.

    "Yes, not tried yet. Everyone knew perfectly well, build pipelines. The theme is clear, the strategic question of building pipelines. Well, of course, in my opinion, everything we imagine is the amount of oil that goes in the pipeline, of course, gets in the Railways. Okay, okay, the tank stand, it's not so bad, by and large, one does not lose much. Now at the same time the Presidium of the state Council, Mr Putin, with your participation, makes a decision about the need to develop waterways and to create an alternative in the season of carriage transport rail river. Dear Ministry of industry in the face Manturov financing refinancing for the construction of vessels. You decide to unleash a narrow host Gorodetsky site. 180 billion rubles in order to increase the traffic on the motorway. So, the river is environmentally friendly, in season, is quite normal. But what's next? Built on more than a hundred vessels at our shipyards, including 60 liquid. And leasing companies, banks, everything, accordingly, was involved, because there is a normal process of government support. And then at the same time last year, we respected the Railways gives a discount during this season it is on the administration of river transport. 25% from transportation of products. Away million tons of cargoes. Accordingly, further investment projects? 2 billion, sorry, $ taken from the River fleet. Russian Railways has received 600 million rubles of profit. It seems to be necessary to think what to do next. Nothing of the sort. This year, an additional 37% discount. Further, accordingly, the court who will build? Why we invested in this theme? First, we put the navigation of the river, and then put again the shipyard. Well, wait, but this is a Smith number two."– cried Lisin.

    "The tractor just don't touch, okay? called Lisin Putin. — That's what Volodya said, it's easy to solve. But it was necessary to conclude an agreement with the government for the construction of vessels. So, the Ministry needs to be a mechanism for payback of these investments. So it was necessary to keep the tariff. Representatives of the government in the Railways had to say about it. And they all rest about the same, different mechanisms need to be established. Very sorry that we still have such basic things, which generally lie on the surface, we did not formulate them. This is a must-do. As for the whole of our intentions in the near future, I think that the government overall, the Ministry of economic development, Ministry of Finance, the Central Bank will work as it should with unions, separate large enterprises, associations of medium and small businesses. We have, I assure you, the mood is very serious, decisive to all, I have already spoken about it publicly to all that prevents us from moving forward, it was stripped".

    Bankers and financiers are talking about reducing inflation, investment and relations with international partners.

    "If I knew that then the relationship will not deteriorate, will be to improve relations, people are now significantly encourage investment. I also heard today from the President that he hopes that steps will be taken to improve mutual relations with the West," — said the Chairman of the Board of the Center for strategic development Alexey Kudrin.

    Putin stressed the mood to create conditions for the increase of efficiency of the national economy.

    "Of course we understand that the most important thing that it was stable. But we will try to do is not only stable, we will try to make more and more efficient from the point of view of business, — said Putin. True, and I think it's clear, sorry, the state should at any variant to meet their social obligations. But still a priority for the near future, we will proceed from the fact that priority is advancing the development of the economy."

    Today, Putin met with members of the RSPP Board in closed session. At the meeting, told the head of the Union of Industrialists and entrepreneurs Alexander Shokhin, one of the key topics was the discussion of a mechanism that would help the businessmen, who had problems in the past with legislation to emerge from the shadows. Commissioned to work on with the business of such a mechanism were members of the Cabinet.

    Friday 09 February 2018 - 22:16:26email to someone printer friendly create pdf of this news item
    Walk-in closets and panoramic Windows: the first settlers are preparing to evaluate a new apartment

    In the new building on 5-th Parkovaya street will move inhabitants of two five-story buildings on the street by Konstantin Fedin. The house, which will be demolished, located just 300 metres from the new place of residence of immigrants.

    As reported "Interfax" the Deputy head of the construction Department Alexander Lomakin, the house organized by the information centre for migrants, it will work since February 10, from 8 a.m. to 9 p.m. seven days a week.

    The house was built in the framework of the program "Housing" apartments brought into compliance with the requirements of the renovation program. The new building is a three-piece monolithic 18-storey building with an area of 31 thousand square meters with the first residential floor.

    In the house of 340 apartments. The floors in the entrance halls of the apartments and kitchens made of granite, rooms – laminate, walls – Wallpaper for painting. Bathrooms are fully stocked with plumbing, space for washing machine.

    The kitchens include electric stoves, balconies with panoramic glazing. In all areas of the apartments have chandeliers, reads the website of the Moscow construction complex.

    The Windows in the apartments of PVC profiles with double glazing and valves of macroprolactinemia. The apartments have walk-in closets or built in wardrobes.

    Friday 09 February 2018 - 22:08:06email to someone printer friendly create pdf of this news item
    SMS Android app will be a universal messenger

    The company Google is preparing a major update messenger Android Messages ("Android" Message), the default for sending SMS. As reported by news site Android Police, who studied code APK file, soon the app will get support for technology Rich Communication Services (RCS), which will allow you to share a regular "text messages" via the Internet.

    As for iMessage (Messages) on the iPhone and Mac owners of Android devices will be able to communicate through a single messenger. If the message can't be delivered over Wi-Fi, it will be sent in the usual way, via the cellular network. Moreover, RCS as an "add-on to SMS" to enable the sharing of high quality images and also see the indicator of what the person is typing.

    The code also mentions that "Android" Message will be able to send messages including computers and different browsers. You will need to go to the site Google and scan a QR code.

    RCS is essentially an analogue of the usual mobile messenger with two fundamental differences. First, sending a message to him, not to worry whether a similar application for the recipient. Even if mobile operator does not support RCS, the message will still come. However, in plain TEXT.

    ”Google and the mobile operators have prepared replacement. read more

    Second, RCS allows operators to control the transmission of messages sent using this technology and, if desired, to charge for them charge. Probably exactly what the mobile operators want to compensate for sharply fallen in recent times, the revenues from SMS.

    Friday 09 February 2018 - 22:08:04email to someone printer friendly create pdf of this news item
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