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    The development of the Russian chemists will help to reduce the percentage of rejection of implants

    Experts of chemical faculty of Tomsk state University (TSU) to develop a new approach to creating composite materials for use in traumatology and orthopedics.

    Scientists have proposed to use a Sol-gel method which will help to improve the structure of bioactive coatings. In turn, this will reduce the percentage of rejection of implants and to accelerate the process of rehabilitation of patients, according to the website of the University.

    The advantages of the Sol-gel synthesis is a high degree of homogeneity of the particles, the possibility of deposition of coatings on materials of any shape and of any size, the purity of the final product.

    "The Sol-gel method have long been known. For example, it is used to produce the nanoparticles," – said the project author, researcher of the Department "New materials for the electrical and chemical industries" HF TSU Ekaterina lutova house.

    She noted that Tomsk experts suggest using a Sol-gel method to create biocompatible composite materials for replacement of damaged or lost fragment of bone tissue of the patient.

    As the basis of a composite is the titanium or its alloys. On a hard surface applied calcium phosphate layer, are necessary to the native tissue of the patient adopted a foreign element. But this layer is often not sufficient for successful implantation.

    According to medical statistics, from 30 to 50 percent of titanium prosthesis installed Russian patients rejected due to postoperative complications, primarily due to active inflammation in the area of attachment of the implant.

    Chemists believe that to minimize the risks using the modification of calcium-phosphate layer on Sol-gel technology, which allows to obtain colloidal solutions thin films on any substrates.


    "Modified layer will regulate a number of important characteristics of the composite," explains Lyutov. In particular, this will allow you to specify the desired size of the particles on the coating surface and improve the wettability of the implant body fluids (blood, plasma), which improves the biocompatibility of the prosthesis with the patient, she adds. The use of the Sol-gel method will ensure the proximity of chemical and phase composition of the implant to the composition of the replaced tissue.

    Along with this, chemists propose to change the composition of the bioactive layer is to complement the traditionally used three-component system of oxides of silicon-phosphorus-calcium titanium oxide or magnesium oxide. This has a positive impact on the timing of accretion and the formation of new bone tissue in the problem area.

    By the way, earlier at the Department of inorganic chemistry was conducted pilot testing of applying bioactive coatings using a Sol-gel method, which confirmed its effectiveness.

    According to Lutovac, new developments will be tested in vitro ("in vitro") and in vivo (inside living organism) they will be tested in the laboratories of the chemistry Department of Tomsk state University and at the Institute of biology and Biophysics of TSU. The results of the research, the scientists will present at the end of 2019. We will add that the researches of chemists supported by the grant of President of Russia.

    By the way, earlier the authors of the project "Conduct.Science" (nauka.vesti.ru) told me about a new implant that fuses with the bone, "repairing" a broken limb. Moreover, it was reported on the hydrogel mimics cartilage tissue, which will help to create the perfect implants for knees.

     
     

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